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ea0011p434 | Endocrine disruptors | ECE2006

Origin of dysgenetic areas in testes of rats exposed to Di n-butyl phthalate (DBP) during fetal life: A model of human testicular dysgenesis syndrome

Mahood IK , Scott HM , Hallmark N , McKinnell C , Walker M , Fisher JS , Sharpe RM

Disorders of male reproductive health, including testicular cancer, cryptorchidism, hypospadias and low sperm counts, are common and may be increasing in incidence. These conditions manifest at different life stages (low sperm counts and testicular cancer in adulthood; cryptorchidism and hypospadias at birth) but are proposed to originate in fetal life. These disorders have therefore been hypothesized to comprise a testicular dysgenesis syndrome (TDS), which result...

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ea0031p291 | Pituitary | SFEBES2013

Is diethylstilboestrol an endocrine disruptor in the developing human fetal testis? Effects of DES exposure using a xenograft approach

Mitchell R T , Anderson R A , van den Driesche S , McKinnell C , MacPherson S , Wallace W H B , Kelnar C J H , Sharpe R M

Context: In rodents, in-utero exposure to the exogenous oestrogen diethylstilboestrol (DES) results in reproductive abnormalities in male offspring. It has been proposed that similar anti-androgenic effects also occur in the human fetal testis following oestrogen exposure.Objective: Determine effects of DES exposure on testosterone production by normally growing human fetal testis xenografts.Design: Human fetal testes (15&...

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Endocrine Abstracts

Origin of dysgenetic areas in testes of rats exposed to Di n-butyl phthalate (DBP) during fetal life: A model of human testicular dysgenesis syndrome

Is diethylstilboestrol an endocrine disruptor in the developing human fetal testis? Effects of DES exposure using a xenograft approach

BiosciAbstracts